Epiphyseal cartilage from a young C57BL/6 mouse before (left) and after (right) sampling using laser-capture microdissection. LCM is an 'old school' technique for molecular profiling different populations of cells within a tissue. Not as technically challenging (or expensive) as the new 'omics' but certainly lower throughput. Mouse bones here were embedded in OCT, frozen, and cut with a cryostat to preserve nucleic acids. Lower resolution of the images is due to the rapid processing/staining steps and the absence of a coverslip.
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